That's a long time now I had read the first comics so I'm not anymore much confident in telling you about how the series starts but the story is around the character of Yorick Brown, a young amateur escape artist, who happens to be the last man on Earth after a strange plague suddenly killed every men on the surface of the globe.
When the disaster happens, Yorick is on the phone with Beth Deville, is girlfriend currenlty working as an anthropologist in Australia. He won't have time to propose her and from now on will try to reach her at the other side of Earth.
He is soon joined by Agent 355 who works for a mysterious US government agency and becomes Yorick's bodyguard; and by the Doctor Allison Mann, an expert geneticist, seeking to discover the cause of the plague and why Yorick survived. Not forgetting Ampersand, Yorick's Capuchin monkey and the only other male mammal who survived the plague.
60 issues is a long run for a graphic novel but it is cut in several 2 or 3 short issues during which the general story evolves as well without ever giving you the feeling it is never going to end
I really liked that series a lot and warmly recommend it !
You can download the first issue from the Vertigo website by clicking HERE.